Note to Hamlet, 3.2.255: "Thoughts black, hands apt, drugs fit, and time agreeing, / Confederate season, else no creature seeing"

Thoughts black, hands apt, drugs fit, and time agreeing, / Confederate season, else no creature seeing: i.e., my thoughts murderous, my hands ready and willing (to commit murder), my poison fit (for the murder), and the opportunity (to do the murder) all come together, (making this) a time which conspires (to commit the murder), when no other creature will see (the murder).