here thy hunters stand / Sign'd in thy spoil, and crimson'd in thy lethe. In the language of hunting, "spoil" was a word for all the parts (such as lungs, kidneys, liver) of a quarry that were fed to the hunting dogs. In the process of butchering the quarry, the hunters were "signed"marked with blood splatters.
"Lethe" is the river of forgetfulness, but perhaps Shakespeare had in mind another river in the underworldCocytus, the river of blood.